How much does a Pro-Safe biosafety cabinet cost?

Pro-Safe Class II A2 biosafety cabinets start at $5,961.22 for the 2 ft model (PLS150). NSF/ANSI 49-certified Class II A2 models start at $7,571.45 (PLS152, 3 ft). Class I models start at $3,309.50. All prices are published — no quote required. [Source: pro-lab-direct.com, April 2026]

Are Pro-Safe biosafety cabinets NSF/ANSI 49 certified?

Pro-Safe Class II A2 models PLS152 (3 ft), PLS153 (4 ft), and PLS154 (6 ft) are NSF/ANSI 49-2024 certified. NSF/ANSI 49-2024 certification requires passing 13 physical and biological challenge tests conducted by an independent testing body. Certification status for other Pro-Safe models — confirm before specifying for BSL-3 environments.

What is the difference between Class II A2 and Class II B2 biosafety cabinets?

Class II A2 cabinets recirculate 70% of air through internal HEPA filters and exhaust 30% — no external ductwork required. Class II B2 cabinets exhaust 100% of air outside the building through dedicated ductwork, making them required for work with volatile chemicals, cytotoxic drugs, or hazardous aerosols. Class II A2 covers BSL 1, 2, and 3 biological work; Class II B2 adds volatile chemical protection. [Source: CDC/NIH BMBL 6th Edition]

Do I need an NSF-certified biosafety cabinet?

NSF/ANSI 49 certification is required by most institutional purchasing policies (universities, hospitals, government labs, pharmaceutical facilities) and for BSL-3 work. It is also required by many accrediting bodies and OSHA 29 CFR 1910.1030 compliance programs. Small diagnostic labs and private labs may use non-certified cabinets for lower-risk work, but certification provides documented evidence of performance for audits and inspections.

How often does a biosafety cabinet need to be certified?

NSF/ANSI 49 requires annual field recertification of certified cabinets. Recertification must be performed by an NSF-accredited field certifier and is required after relocation, HEPA filter replacement, or any modification to the cabinet configuration. Typical cost: $125–$150 per unit per year. [Source: NSF/ANSI 49-2024; ABSA International guidance]

Does Class II A2 require external ductwork?

No. Class II A2 biosafety cabinets (including all Pro-Safe PLS150–PLS204 and NSF-certified PLS152, PLS153, PLS154 models) operate without external ductwork by recirculating 70% of air through internal HEPA filters. Only Class II B2 and Class III cabinets require dedicated external exhaust ductwork. This eliminates $2,000–$8,000 in typical ductwork installation costs.

What culture media and reagents work in a Pro-Safe biosafety cabinet?

Any standard clinical microbiology culture media and identification reagents can be used in a Pro-Safe Class II A2 cabinet. Pro-Lab Diagnostics USA — the manufacturer of Pro-Safe cabinets — also supplies culture media, strep/staph/E. coli identification test kits, oxidase reagents, coagulase reagents, and microbank cryogenic preservation systems. Purchasing equipment and consumables from the same manufacturer simplifies procurement and ensures workflow compatibility.

NSF-Certified Biosafety Cabinets from $7,571

Name: Pro-Safe Class II A2 Biosafety Cabinet — NSF/ANSI 49-2024 Certified (PLS152)
Brand: Pro-Safe
SKU: PLS152
Price: 7571.45 USD
Availability: InStock

Best Seller

Pro-Safe PLS150 — 2 ft Class II A2

The Lab's Favorite Biosafety Cabinet

Our most-ordered model. Published price, instant checkout, direct from the manufacturer — no distributor markup, no quote required.

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#1 Best Seller

The PLS150 is our highest-volume model — trusted by BSL-2 labs, universities, and clinical facilities nationwide. Ships direct, no wait on quotes.

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Best Price — Published & Guaranteed

Starting at $3,309.50 — the lowest direct price for a Class II A2 cabinet. No hidden fees, no distributor markup. What you see is what you pay.

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Volume Discounts Available

Ordering 2 or more cabinets? Contact us for tiered pricing. Labs outfitting multiple rooms or facilities regularly save 8–15% on multi-unit orders.

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Same Certification as Labconco — Lower Price

Pro-Safe Class II A2 NSF models (PLS152, PLS153, PLS154) carry NSF/ANSI 49-2024 certification — independently awarded after 13 physical and biological challenge tests. Same credential your accreditor requires. Starting at $7,571.

NSF/ANSI 49-2024 | product page — Confirmed

Save $4,000–$7,000 per cabinet vs. Labconco or Thermo Fisher trending_down

payments

No Quote Games

Every Pro-Safe model has a price on the page. Class I from $3,309. Class II A2 NSF-certified from $7,571. Class III at $19,521. Instant checkout available for standard models.

air

Class II A2 Runs Without Ductwork

Pro-Safe Class II A2 recirculates 70% of air through internal HEPA filters — no external ductwork installation required. Eliminate $2,000–$8,000 in typical ductwork costs.

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Cabinet + Consumables. One Manufacturer.

Pro-Lab Diagnostics USA makes Pro-Safe cabinets and the culture media, identification reagents, and test kits used inside them. Order your BSC and your microbiology consumables on the same purchase order.

pro-lab-direct.com catalog — Confirmed

science

Tailored for Your Role

Redirect $4,000–$7,000 Per Cabinet Toward Your Research Budget

Capital budget allocated to containment equipment shouldn't crowd out reagents, personnel, or instrumentation. Pro-Safe NSF-certified Class II A2 cabinets pass the same NSF/ANSI 49-2024 standard as premium brands — at a published price your budget office can approve without a quote cycle. PLS152 (3 ft), PLS153 (4 ft), and PLS154 (6 ft) are certified. The price difference funds the rest of the lab.

check_circle NSF/ANSI 49-2024 certified — same credential as Labconco and Thermo Scientific, independently awarded
check_circle Published price from $7,571 — no quote required, no distributor markup
check_circle Class II A2 covers BSL 1, 2, and 3 biological work per CDC/NIH BMBL 6th Edition

NSF/ANSI 49 Certified. Documented. Field-Recertifiable by Any Accredited Certifier.

Your audit documentation requires certified performance — not brand preference. Pro-Safe Class II A2 models PLS152, PLS153, and PLS154 carry NSF/ANSI 49-2024 certification, satisfying OSHA 29 CFR 1910.1030 biosafety cabinet requirements and institutional compliance programs. Any NSF-accredited field certifier can perform annual recertification — certification is tied to the equipment standard, not the manufacturer's service network.

check_circle NSF/ANSI 49-2024: 13 physical tests including biological challenge testing
check_circle Annual field recertification by any NSF-accredited certifier — not brand-specific
check_circle ISO 13485:2016 quality system — manufacturer quality documentation available on request

Published Price. No Quote Required. Full Class Range. One PO.

Every Pro-Safe model has a price on the page. Class I from $3,309. Class II A2 NSF-certified from $7,571. Class III at $19,521. No rep callback, no distributor quote, no hold music. If your lab already orders Pro-Lab culture media or test kits, add the cabinet to the same purchase order.

Class	Price From	NSF/ANSI 49	Ductwork
Class I	$3,309.50	Contact us for status	No
Class II A2	$5,961.22	✅ PLS152, PLS153, PLS154	No
Class II B2	$7,699.50	Contact us for status	Required
Cytotoxic Cabinet	$14,104.37	Contact us for status	Required
Class III	$19,520.61	Contact us for status	Required

NSF-Certified. Direct Price. No Distributor Markup.

Private and contract labs need NSF/ANSI 49 certification to satisfy clinical accreditors — but you don't need to pay premium brand prices to get it. Pro-Safe PLS152, PLS153, and PLS154 carry NSF/ANSI 49-2024 certification and list at $7,571–$9,181 with no quote required. If you're already ordering culture media or test kits from Pro-Lab Direct, your BSC ships from the same manufacturer.

check_circle NSF/ANSI 49-2024 certified — satisfies the cabinet certification requirement for CLIA, CAP, and COLA accreditation programs
check_circle Class II A2 covers routine clinical microbiology — BSL 1, 2, and 3
check_circle No external ductwork required — Class II A2 runs on standard electrical

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Pro-Cool™ Ultra-Low Temperature Freezer

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Microbank® PL.170C Cryopreservation System

PL.170C-Series

Microbank® Microbial Preservation System

Inoculate and store organism stocks inside the Pro-Safe™ biosafety cabinet, then freeze at –70°C in Pro-Cool™.

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TransVelopes® Specimen Transport Bags

Biohazard specimen bags for safe handling of infectious specimens under the Pro-Safe™ biosafety cabinet.

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Class II A2 NSF-Certified Models

NSF/ANSI 49-2024 certified — same standard as Labconco and Thermo Fisher. Published prices, no quote required.

Model	Size	NSF Cert	Airflow	BSL	Features	Price
PLS152	3 ft	check_circle NSF/ANSI 49-2024	70% recirc / 30% exhaust	BSL 1, 2, 3	LED, UV lamp, LCD, motorized sash	$7,571.45
PLS153	4 ft	check_circle NSF/ANSI 49-2024	70% recirc / 30% exhaust	BSL 1, 2, 3	LED, UV lamp, LCD, motorized sash	$8,078.19
PLS154	6 ft	check_circle NSF/ANSI 49-2024	70% recirc / 30% exhaust	BSL 1, 2, 3	LED, UV lamp, LCD, motorized sash	$9,181.12

Delivery: 5–7 weeks. Voltage: 110V or 220V. Class II A2 — no external ductwork required. All prices published — pro-lab-direct.com, April 2026.

Full Class Range — All Models

Class I through Class III and Cytotoxic Safety Cabinets. Class II B2, Class III, and Cytotoxic models require dedicated external ductwork. Contact us for NSF certification status on non-NSF-listed models.

Class	Models	Price From	NSF/ANSI 49	Ductwork
Class I	PLS100–PLS103	$3,309.50	Contact us for status	No
Class II A2 (standard)	PLS150–PLS151	$5,961.22	Contact us for status	No
Class II A2 (NSF)	PLS152–PLS154	$7,571.45	✅ NSF/ANSI 49-2024	No
Class II B2	PLS225–PLS228	$7,699.50	Contact us for status	Required
Cytotoxic Cabinet	PLS250	$14,104.37	Contact us for status	Required
Class III	PLS301	$19,520.61	Contact us for status	Required

Source: pro-lab-direct.com product pages — Confirmed, April 2026. For Class II B2, Class III, and Cytotoxic models, click "Get a Quote" to send specifications and receive pricing within one business day.

Pro-Safe vs. the Competition

Same NSF/ANSI 49-2024 certification. Real price difference.

Spec	Pro-Safe PLS152 (3 ft)	Labconco Purifier Logic	Thermo Scientific 1300 Series
NSF/ANSI 49 Certified	✅ NSF/ANSI 49-2024	✅ Certified	✅ Certified
Starting price (3 ft)	$7,571 — published	~$12,000–$15,000 — quote required	~$10,000–$14,000 — quote required
Price transparency	✅ Published — no quote needed	❌ Quote required via distributor	❌ Quote required (Fisher Scientific)
Airflow (Class II A2)	70% recirc / 30% exhaust	70% / 30%	70% / 30%
External ductwork	Not required	Not required	Not required
BSL coverage	BSL 1, 2, 3	BSL 1, 2, 3	BSL 1, 2, 3
Available direct	✅ Direct from manufacturer	❌ Distributor required	❌ Fisher Scientific required
Consumable ecosystem	✅ Culture media + test kits	❌ None	❌ None (Fisher-branded only)

Source: Pro-Safe price — pro-lab-direct.com, April 2026 (Confirmed). Labconco and Thermo Scientific prices — estimated from distributor listings; contact vendors for current quotes. NSF certification status for Labconco and Thermo Scientific — Corroborated from manufacturer pages.

Complete Your Lab Workflow

Pro-Lab staining reagents — Gram's iodine, crystal violet, malachite green and more

Pro-Stains™ Microbiology Stains

Gram's iodine, crystal violet, malachite green, and more — staining reagents used daily at the BSC workbench.

View Pro-Stains™ arrow_forward

Prolex™ Streptococcal Grouping Kit

Rapid latex agglutination for Groups A, B, C, D, F, and G — a standard ID test performed inside the biosafety cabinet.

View Prolex™ Strep arrow_forward

Microbank® PL.170C Cryopreservation System — vials and cryoboxes for organism storage

Microbank™ Preservation

Strain preservation and banking — performed inside the biosafety cabinet workflow.

View Microbank® arrow_forward

Frequently Asked Questions

Pro-Safe Class II A2 cabinets start at $5,961.22 (PLS150, 2 ft). NSF/ANSI 49-certified models start at $7,571.45 (PLS152, 3 ft), $8,078.19 (PLS153, 4 ft), and $9,181.12 (PLS154, 6 ft). Class I models start at $3,309.50. Class II B2 starts at $7,699.50. Class III is $19,520.61. All prices are published on the product page — no quote required. Source: pro-lab-direct.com product pages — Confirmed, April 2026

Pro-Safe Class II A2 models PLS152 (3 ft), PLS153 (4 ft), and PLS154 (6 ft) are NSF/ANSI 49-2024 certified. NSF/ANSI 49-2024 certification is independently awarded after 13 physical and biological challenge tests — the same credential required by institutional accreditors and OSHA 29 CFR 1910.1030 compliance programs. Certification status for other Pro-Safe models — contact Pro-Lab Diagnostics USA to confirm. Do not specify non-confirmed models for BSL-3 environments without verification. Source: NSF/ANSI 49-2024 standard; product page — Confirmed

Class II A2 recirculates 70% of air through internal HEPA filters and exhausts 30% — no external ductwork required. Class II B2 exhausts 100% of air outside the building through dedicated ductwork; it is required for volatile chemicals, cytotoxic drugs, or hazardous aerosols. Class II A2 covers BSL 1, 2, and 3 biological work; Class II B2 adds volatile chemical protection. Pro-Safe Class II A2 models (PLS150–PLS154) do not require ductwork. Pro-Safe Class II B2 models (PLS225–PLS228) require dedicated external exhaust. Source: Class standard characteristics — Confirmed; CDC/NIH BMBL 6th Edition — Confirmed

NSF/ANSI 49 certification is required by most institutional purchasing policies (universities, hospitals, government labs, pharma) and for BSL-3 work. It is required for OSHA 29 CFR 1910.1030 (Bloodborne Pathogens Standard) compliance programs. Small private or contract labs working at BSL 1–2 may use non-certified cabinets, but certification provides documented evidence for accreditation audits and inspections (CAP, CLIA, COLA). Source: OSHA 29 CFR 1910.1030 — Confirmed; NSF/ANSI 49-2024 — Confirmed; CDC/NIH BMBL 6th Ed. — Confirmed

NSF/ANSI 49 requires annual field recertification by an NSF-accredited field certifier. Recertification is also required after HEPA filter replacement, relocation, or any modification to the cabinet configuration. Typical annual recertification cost: $125–$150 per unit. Recertification is field-portable — any NSF-accredited certifier can recertify a Pro-Safe cabinet, not just manufacturer service. NSF maintains a directory of accredited field certifiers at nsf.org. Source: NSF/ANSI 49-2024 — Confirmed; cost range — Corroborated from ABSA International guidance

No. Class II A2 cabinets — including all Pro-Safe Class II A2 models (PLS150–PLS154, NSF-certified PLS152, PLS153, PLS154) — operate without external ductwork. The 70%/30% airflow configuration recirculates filtered air internally. Only Class II B2, Class III, and Cytotoxic models require external ductwork. Eliminating ductwork installation saves $2,000–$8,000 in typical setup costs. Source: Class II A2 standard characteristic — Confirmed; ductwork cost range — Corroborated, industry data

Yes — NSF/ANSI 49-certified Class II A2 cabinets are appropriate for BSL-3 work per CDC/NIH Biosafety in Microbiological and Biomedical Laboratories (BMBL), 6th Edition, provided the cabinet is properly maintained and annually recertified. Pro-Safe NSF-certified models PLS152, PLS153, and PLS154 meet this requirement. Non-certified models should not be used for BSL-3 work without independent performance verification. Source: CDC/NIH BMBL 6th Edition — Confirmed; NSF certification on product pages — Confirmed

Class II A2 cabinets should not be used for work involving volatile toxic chemicals, volatile radionuclides, or cytotoxic drugs — these require a Class II B2 or Class III cabinet with 100% external exhaust to prevent buildup of hazardous vapor. Class II A2 recirculates air internally; volatile compounds accumulate. Use Class II B2 (Pro-Safe PLS225–PLS228) or the Pro-Safe Cytotoxic Cabinet (PLS250) for these applications. Source: CDC/NIH BMBL 6th Edition — Confirmed; Class standard characteristics — Confirmed

Equipment Compliance Disclosures

NSF/ANSI 49 Certification

Pro-Safe Class II A2 Biosafety Cabinet models PLS152, PLS153, and PLS154 are NSF/ANSI 49-2024 certified. Certification was independently awarded by an NSF-accredited testing organization after completing all required physical and biological challenge tests per NSF/ANSI 49-2024. Certification documentation available upon request.

ISO 13485:2016 Quality System

Pro-Lab Diagnostics USA operates under an ISO 13485:2016 certified quality management system. ISO 13485:2016 certification documentation is available for vendor qualification purposes.

BSL Classification Guidance

Biosafety level (BSL) cabinet requirements per CDC/NIH Biosafety in Microbiological and Biomedical Laboratories (BMBL), 6th Edition: BSL 1 and 2 — Class I or Class II A2 recommended; BSL 3 — NSF/ANSI 49-certified Class II A2 or higher required; BSL 4 — Class III required. Contact your Institutional Biosafety Committee (IBC) for facility-specific requirements.

OSHA Compliance

Annual field certification of biosafety cabinets is required under OSHA 29 CFR 1910.1030 (Bloodborne Pathogens Standard). Pro-Safe NSF/ANSI 49-certified models (PLS152, PLS153, PLS154) can be field-recertified annually by any NSF-accredited field certifier. NSF maintains a directory of accredited field certifiers at nsf.org.

Safety Operating Notice: Biosafety cabinets must be operated by trained personnel following institutional biosafety protocols. Cabinet use for work with infectious agents must be conducted in accordance with BSL requirements of your Institutional Biosafety Committee (IBC) and CDC/NIH BMBL guidelines. Do not operate a Class II A2 cabinet with volatile toxic chemicals, volatile radionuclides, or cytotoxic drugs — use Class II B2 or Class III for these applications.

Ready to Equip Your Laboratory?

Choose the path that fits your procurement workflow. NSF-certified Class II A2 from $7,571 — published, no distributor, no quote required.

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Class I and Class II A2 — add to cart, checkout direct. All prices published.

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Class II B2, Class III, Cytotoxic, or 3+ unit orders. Response within one business day.

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Talk to a Specialist

15 minutes — class selection, NSF documentation, multi-unit pricing, net-30 terms.

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Request NSF Documentation

Certification records for PLS152, PLS153, PLS154 — for purchasing or EHS files.

NSF-Certified Biosafety Cabinets — Direct from $7,571