For In Vitro Diagnostic Use Only|Kauffmann-White Scheme|FDA BAM Ch. 5 Compatible|Cold Ship — 2-Day Guaranteed|Pro-Lab Diagnostics, Ontario, Canada
Trusted by clinical microbiology and public health laboratories
"Vision Antisera earns its name — results are read with the naked eye in minutes, no instrumentation required."
"Antisera isn't a commodity you can grab off a shelf — global production is limited, the manufacturing process is complex, and most suppliers can't keep up. Pro-Lab's international sourcing network means we have access when domestic suppliers don't. Order early, plan ahead, and you'll have product when your competitors are waiting."
Why Labs Choose Vision Antisera
Every product in the portfolio ships cold-chain in 2 days and carries a 2-year shelf life.
calendar_month
2-Year Shelf Life Reduces Reagent Waste
Designed for labs that run antisera episodically — outbreak response, food safety investigations, reference confirmations.
Pro-Lab Direct Product Specifications
local_shipping
Cold Chain Maintained — Arrives in 2 Business Days
All antisera cold-shipped at 2–8°C with 2-day delivery. Temperature integrity maintained from facility to your receiving dock.
pro-lab-direct.com shipping specifications
flag
Covers Every CDC-Reportable Enteric Pathogen
Salmonella, Shigella, Vibrio cholerae, and pathogenic E. coli are all NNDSS-notifiable. One supplier, every mandatory serotyping workflow.
CDC NNDSS (cdc.gov/nndss)
storefront
Direct-to-Lab Pricing — No Distributor Markup
Order online at pro-lab-direct.com without a distributor account. Pricing is visible, no login required, ships direct from the manufacturer.
pro-lab-direct.com
What Brings Your Lab Here?
When Your Supplier Backordered, Your Lab Still Had Isolates to Type
Pro-Lab Direct maintains independent manufacturing stock — separate from Thermo Fisher's US supply chain. When your primary supplier can't deliver, we ship in 2 days. Our 2-year shelf life means a single qualifying purchase covers your surge capacity for outbreak season without committing to large minimum orders.
Confirmed — CDC NNDSS
Salmonella O Polyvalent A–I (PLA003) enables rapid initial serogroup screening before individual O-type confirmation — reducing isolate turnaround for CDC-required reporting.
Confirmed — Product Spec
2-year shelf life from manufacture reduces annual revalidation burden for low-to-medium volume clinical labs.
Confirmed — WHO/CDC
Kauffmann-White alignment ensures serotype results are reportable to state and CDC systems without conversion.
Outbreak Response Can't Wait for a Backorder
State and county public health labs carry mandatory NNDSS reporting obligations. When an isolate needs serotype confirmation, you need the reagent today. Pro-Lab ships Salmonella O/H/Vi, Shigella, Vibrio cholerae, and E. coli antisera from manufacturer stock — 2-day cold chain delivery, individual serotype ordering, no minimum lot requirements.
Confirmed — CDC NNDSS
Vibrio cholerae O139 antiserum (PLA494) available — covers the non-O1 pandemic serogroup required for cholera outbreak investigation.
Confirmed — WHO/CDC Standard
Salmonella O Polyvalent A–I Kit (PLA003) is the standard first-pass screening step per Kauffmann-White scheme before individual serogroup confirmation.
Confirmed — Product Listing
Positive control antisera for Widal and Weil-Felix tests (PLA581–613) support serology-based typhoid and rickettsial disease investigations.
FDA BAM Requires Antisera Confirmation — Ship in 2 Days
FDA Bacteriological Analytical Manual Chapter 5 requires serological confirmation with O and H antisera for definitive Salmonella identification in food matrices. Pro-Lab's antisera are aligned with BAM methodology and carry a 2-year shelf life — essential for food safety labs with batch or episodic testing workflows.
Confirmed — FDA BAM Ch. 5
FDA BAM Chapter 5 specifies serological confirmation using O and H antisera following the Kauffmann-White scheme for Salmonella in food matrices.
Confirmed — Product Listing
E. coli O111 (PLA527), O55 (PLA525), O119 (PLA529), and O78 (PLA526) antisera cover STEC serotypes common in food safety outbreak investigations.
Confirmed — Product Spec
2-year shelf life reduces per-investigation amortized cost for labs with episodic testing volumes.
Full Antisera Catalog
All products ship cold. 3ml vials, 2-year expiration from manufacture date.
Multiple sources available. If you can't find the serotype you need, contact us — we may be able to help source it. Antisera can be tricky and may take time to fulfil, but we'll do our best.
The portfolio covers Salmonella (O serogroups A–I, H types, Vi), Shigella (dysenteriae type 12, flexneri types 1/2/6/X/Y/Z, boydii types 1/2/3), Vibrio cholerae (O1 Polyvalent, Inaba, Ogawa, O139, O141), and pathogenic E. coli (O:K serotypes PLA521–530). Widal and Weil-Felix antigens and positive control antisera are also available.
Antisera are used in slide agglutination tests. A small colony is emulsified in saline on a glass slide, a drop of antiserum is added, and the slide is rocked gently for up to 2 minutes. Visible clumping (agglutination) indicates a positive reaction — confirming the organism's surface antigen matches the antibody specificity of the antiserum. The procedure requires no instrument and yields results in ≤2 minutes.
Salmonella, Shigella, Vibrio cholerae, and pathogenic E. coli serotypes are all CDC-reportable notifiable pathogens under NNDSS, and serotyping is required for confirmed identification for public health reporting. FDA BAM Chapter 5 also requires serological confirmation with antisera for Salmonella in food safety testing.
Pro-Lab antisera carry a 2-year shelf life from the manufacture date. Store at 2–8°C and do not freeze. Once opened, follow the IFU storage guidance. The 2-year shelf life is designed for labs that run serotyping episodically rather than at daily clinical volume.
A Widal test requires antigens for patient specimen testing (PLA301–308: Salmonella Paratyphi A/B/C-O, Typhi O and H, Proteus OX2/OX19/OXK) plus positive control antisera (PLA581–613) for quality control. All are available individually from pro-lab-direct.com.
Antisera should not be used on mixed cultures — a pure isolate on appropriate selective media is required before serotyping. Rough or autoagglutinating strains may produce false-positive reactions; these must be excluded using a saline control. Antisera serotyping confirms phenotypic antigen expression and does not replace molecular confirmation for definitive speciation in outbreak investigations.
Yes. Pro-Lab antisera use the same agglutination method and Kauffmann-White scheme as equivalent products from other manufacturers. Lateral substitution validation is a standard procedure — typically one shift with ATCC reference strains. We provide a suggested validation protocol on request aligned with CAP Microbiology Checklist requirements.
Regulatory Information
For In Vitro Diagnostic Use Only.
Test Principle: Polyclonal rabbit antibodies bind to specific somatic (O), flagellar (H), or capsular (K/Vi) antigens on the surface of bacterial cells. Antigen-antibody cross-linking causes visible agglutination (clumping) within 1–2 minutes on a slide. Absence of agglutination indicates no matching surface antigens.
Intended Use: [GAP — IFU not obtained. Exact intended use statement required from Pro-Lab before launch. See intelligence-brief.md Gap #1.]
Limitations: Antisera confirm phenotypic antigen expression only. Autoagglutinating or rough strains will agglutinate in saline control and results are not interpretable. Cross-reactivity between antigenically related serotypes may occur. Do not use on mixed cultures.
QC Requirements: Positive and negative controls must be run each day of use per CLIA/CAP requirements. Document lot number, expiry date, and control results per laboratory's QC policy.
Storage: 2–8°C; do not freeze. Cold chain maintained during shipping.
Safety: PPE required — nitrile gloves, eye protection; standard BSL-2 biological precautions. Dispose of biological reagents per institutional biosafety policy (autoclave or chemical inactivation). Shigella antisera (PL.6900–PL.6903) contain thimerosal — a mercury-based preservative. Handle with care; do not dispose down the drain. Source: Shigella Antisera IFU (Pro-Lab Diagnostics). SDS for remaining PLA series pending — request from Pro-Lab before launch.
Pro-Lab Diagnostics Inc., Ontario, Canada. For technical support: pro-lab-direct.com
Ready to Order or Get a Quote?
Ships cold in 2 business days. Net 30 available for qualified labs. Individual serotype ordering — no minimum lot.
Stay Informed on Antisera Availability
One update per month — new antisera in stock, serotyping protocols, and supply availability alerts. No spam.
