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Pro-Mag™ PLM-2000 isolates total RNA from any sample type using silica-coated magnetic beads. Validated for LAMP, RT-PCR, and real-time PCR. 100 preparations per kit.
Silica-coated magnetic beads bind RNA in solution. No membrane columns to clog, no centrifuge required with optional PLM-2001/2002/2003 racks. Cleaner extractions from challenging sample types including mucus-rich respiratory specimens.
Confirmed — product description, pro-lab-direct.comPro-Mag™ PLM-2000 is specifically validated for Loop Mediated Isothermal Amplification (LAMP). LAMP requires higher RNA purity than PCR — silica magnetic bead chemistry removes inhibitors that would block Bst polymerase. No major competitor publishes LAMP-specific extraction validation.
Confirmed — product page: "validated applications: LAMP"The magnetic bead protocol eliminates centrifuge wait time at each step. Rapid lysis buffer, bead binding, magnetic separation, and elution deliver ready-to-use RNA faster than column-based methods with no sacrifice in purity.
Claimed — manufacturer: "total RNA within minutes" (pro-lab-direct.com)RNases are everywhere. Even trace contamination destroys RNA templates. Pro-Mag™ buffers undergo RNase-free quality control testing on every lot before release — protecting your extractions at the reagent manufacturing level.
Confirmed — product page: "RNase-free QC on all buffer components"Column-based extraction kits were designed for PCR. LAMP is a different reaction — Bst polymerase is significantly more sensitive to inhibitors than Taq. Residual heme, protein carryover, and humic acids that PCR tolerates will block LAMP entirely. Pro-Mag™ PLM-2000 uses silica-coated magnetic beads that remove these inhibitors more completely, and it has been validated specifically for LAMP workflows. Pair it with Optigene Genie® instruments — also available on pro-lab-direct.com — for an integrated extraction-to-detection workflow from a single vendor ecosystem.
Spin column clogging during RNA extraction is the most common per-extraction failure. Each clogged column means a rerun, a QC note, and a delayed result. Pro-Mag™ PLM-2000 eliminates the column entirely. Silica magnetic beads capture RNA in solution — use the optional magnetic rack (PLM-2001/2002/2003) to hold the beads while you pipette off the wash buffer. No centrifuge. No clogging. Validated for LAMP, RT-PCR, and qPCR downstream.
Genie II / Genie III / Genie HT
Real-time LAMP detection platforms. Pro-Mag™ RNA extracts feed directly into Genie for isothermal amplification results — extraction and detection from one vendor.
View Genie® Instruments →ISO-004 — Optigene
Optigene's isothermal amplification mastermix. LAMP-validated RNA from PLM-2000 pairs directly with GspSSD2.0 for a complete lysis-to-result workflow.
View Mastermix →
PLD001 / PLD010
Single-use inoculating loops for specimen handling and transfer. Required for workflows where sample transfer to extraction tube is part of the protocol.
View Pro-Loops™ →| Specification | Value | Source |
|---|---|---|
| Catalog Number | PLM-2000 | pro-lab-direct.com product page [Confirmed] |
| Kit Format | Silica-coated magnetic beads + optimized RNase-free buffers | pro-lab-direct.com [Confirmed] |
| Preparations per Kit | 100 preparations | pro-lab-direct.com [Confirmed] |
| Validated Applications | LAMP (Loop Mediated Isothermal Amplification), Real-time PCR (qPCR), Reverse Transcription-PCR (RT-PCR) | pro-lab-direct.com [Confirmed] |
| QC Standard | RNase-free QC — all buffer components tested per lot before release | pro-lab-direct.com [Confirmed] |
| Throughput | Scalable — flexible sample processing for low- and high-throughput labs | pro-lab-direct.com [Claimed] |
| Protocol | Quick, easy protocol — lysis, bead binding, magnetic wash, elution | pro-lab-direct.com [Claimed] |
| Centrifuge Required | Not required when using magnetic separator racks (PLM-2001/2002/2003) | Product format [Confirmed] |
| Accessory SKUs | PLM-2001, PLM-2002, PLM-2003 (optional magnetic separator racks) | pro-lab-direct.com [Confirmed] |
| Regulatory Classification | For Research Use Only — Not intended for the diagnosis, prevention, or treatment of disease | IFU PLM-2000 ver-20200514 [Confirmed] |
| Manufacturing Standard | ISO 13485 Quality Management System (Pro-Lab Diagnostics) | Corroborated — Pro-Lab corporate standard |
| CE Mark | Assumed — Pro-Lab Diagnostics standard (Flag: confirm CE number for PLM-2000) | FLAG — confirm from regulatory files |
| Pricing | Quote-based — contact Pro-Lab Direct for institutional pricing | pro-lab-direct.com [Confirmed — no price listed] |
| Product Page | pro-lab-direct.com/product-p/plm-2000.htm | Volusion product catalog |
Storage: Lysis Buffer — room temperature. Binding Beads, Wash Buffer, Elution Buffer — 2–8°C. Do not freeze. Stable for at least 1 year. Buffers contain sodium azide (0.05%) as preservative — do not dispose down the drain. Source: IFU PLM-2000 ver-20200514.
Pro-Mag™ PLM-2000 is designed for flexible sample processing across diverse sample types used in clinical and research molecular diagnostics. Compatible sample types include respiratory specimens (nasopharyngeal swabs, nasal swabs, bronchoalveolar lavage), whole blood, serum, plasma, urine, stool, tissue, and environmental samples. Contact Pro-Lab technical support for sample-specific guidance or to request the full Instructions for Use.
Pro-Mag™ PLM-2000 is designed for rapid RNA isolation — the manufacturer describes "total RNA within minutes." The silica-coated magnetic bead protocol (lysis, bind, wash, elute) eliminates centrifugation wait time at each step, making it faster than column-based methods that require centrifugation at every wash step. Contact Pro-Lab technical support for protocol timing data specific to your sample type and throughput requirements.
Pro-Mag™ PLM-2000 is validated for LAMP (Loop Mediated Isothermal Amplification). Optigene Genie® instruments — Genie II, Genie III, and Genie HT — are LAMP detection platforms. PLM-2000 RNA output is designed to serve as direct input for LAMP reactions, making it the natural extraction kit for labs operating Optigene Genie instrumentation. Both PLM-2000 and Optigene Genie instruments are available on pro-lab-direct.com from the same vendor ecosystem. Book a technical call to discuss your specific LAMP workflow.
Column-based extraction (e.g., Qiagen QIAamp) binds RNA to a silica membrane in a spin column and requires centrifugation at each wash step — typically 3–5 centrifuge spins per extraction. Magnetic bead extraction (Pro-Mag™ PLM-2000) binds RNA to silica-coated beads suspended in solution, then uses a magnetic separator rack to hold the beads against the tube wall while wash buffers are pipetted away. No centrifuge spins. No column membrane to clog. The magnetic bead approach also removes inhibitors (heme, protein, humic acid) more completely from complex sample matrices — which is critical for LAMP, where Bst polymerase is highly sensitive to these inhibitors.
Pro-Mag™ PLM-2000 includes RNase-free quality control testing on all buffer components — every buffer lot is tested for RNase activity before release. RNases are ubiquitous environmental contaminants that degrade RNA during and after extraction, leading to failed amplification and false-negative results. Lot-level RNase QC is a manufacturing control that protects RNA integrity at the source — before the kit reaches your lab. This is a confirmed quality specification stated on the Pro-Mag product page.
The PLM-2001, PLM-2002, and PLM-2003 are optional magnetic separator racks that complete the no-centrifuge extraction workflow. Without a magnetic rack, you would need a centrifuge to pellet the beads at each wash step. The racks hold the magnetic beads against the tube wall using a permanent magnet, allowing you to pipette off wash buffer manually. If your laboratory already has a compatible magnetic separator from another application, contact Pro-Lab technical support to confirm compatibility before purchasing the accessory racks.
LAMP (Loop Mediated Isothermal Amplification) requires higher RNA purity than standard PCR. LAMP uses Bst DNA polymerase (from Bacillus stearothermophilus), which lacks the error-correction mechanism of Taq polymerase and is significantly more sensitive to inhibitors. Heme (from blood), humic acids (from soil/stool), and protein carryover that merely reduce PCR efficiency will completely block LAMP amplification. This is why LAMP-specific extraction validation is a technical requirement, not a marketing claim. Pro-Mag™ PLM-2000 has been validated specifically for LAMP to confirm that inhibitor removal meets the higher purity standard that isothermal amplification demands.
Storage temperature and shelf life for Pro-Mag™ PLM-2000 should be obtained from the kit Instructions for Use (IFU) included with the product. Do not assume storage conditions — always refer to the IFU for confirmed storage requirements for the magnetic beads and each buffer component. Contact Pro-Lab technical support to request the IFU or regulatory documentation package. For pricing and ordering, use the Request Quote button on this page or call Pro-Lab Direct at 512-789-5214.
PLM-2000 — 100 preps. LAMP-validated. RNase-free QC. Quote-based pricing.
Add PLM-2000 to your order. Include magnetic racks (PLM-2001/2002/2003) for a complete no-centrifuge workflow.
Ordering 200+ preps per month? Request volume pricing for PLM-2000 and magnetic rack accessories.
Speak with a Pro-Lab molecular diagnostics specialist about LAMP validation, protocol transfer, or documentation requirements.
Request the Instructions for Use (IFU), lot-release certificate, or ISO 13485 documentation package for PLM-2000.
Get the LAMP Extraction Protocol Guide — magnetic bead vs. column comparison for isothermal amplification workflows. Approximately 2–4 emails/month from Pro-Lab Direct.
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