Molecular Results in ≤3.5 Minutes.
The only LAMP platform with published independent evidence its enzyme outperforms NEB WarmStart in Salmonella LAMP assay — 10× more sensitive, USDA-commissioned (Domesle 2022, J AOAC Int; as of April 2026). ISO 13485:2016 ANAB accredited. Eiken Chemical licensed.
GspSSD2.0 delivered results in ≤3.5 minutes in a USDA-commissioned study comparing it directly against NEB WarmStart under identical conditions.
Domesle et al., J AOAC Int 2022 — PMID 35575315
biotech
10× More Sensitive Than NEB WarmStart
The same USDA study found NEB WarmStart showed 10-fold reduced sensitivity compared to GspSSD2.0 across 7 animal food matrices.
Domesle et al., J AOAC Int 2022 — PMID 35575315
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No Thermal Cycler Required
LAMP amplifies DNA at a single constant temperature. No ramp optimization, no thermal cycling programming, no PCR infrastructure.
LAMP technology — product specs
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98.8% Clinical Sensitivity
The Genie III fluorimeter achieved 98.8% sensitivity and 97.7% specificity across 230 human clinical specimens in an independently funded study.
Ibarra-Meneses et al., Microorganisms 2021 — PMID 33809454
10x
Sensitivity
Domesle et al., J AOAC Int 2022 — PMID 35575315
≤3.5
Minutes
Fastest published LAMP time-to-positive
$3.35
Per Reaction
GspSSD2.0 (ISO-004) — 300 reactions/kit
96-Sample LAMP Throughput for $34,999 — No Thermal Cycler Required
The Genie® HT runs 96 LAMP reactions simultaneously at constant 65°C — full random access, dual-channel fluorescence, modular configuration. At $34,999.99 (refurbished by Pro-Lab Diagnostics; list: $75,000 new), it delivers PCR-comparable molecular throughput at 53% below the capital cost of new equipment.
check_circleGenie HT: 96 samples/run, modular 12-block configuration, full random access
check_circle$34,999.99 (refurbished by Pro-Lab Diagnostics) vs $75,000 new list — 53% below new list
check_circle98.8% sensitivity published — independent, EU-funded clinical study (PMID 33809454)
GspSSD2.0: The Fastest LAMP Enzyme in Published Head-to-Head Comparison
An independent USDA-commissioned study published in J AOAC Int compared GspSSD2.0 and NEB WarmStart under identical Salmonella LAMP conditions across 7 food matrices. GspSSD2.0 delivered results in 3.5 minutes; NEB WarmStart showed 10-fold lower sensitivity. GspSSD2.0 also outperformed GspM2.0, GspM, and Tin exo DNA polymerases in head-to-head fluorometric LAMP.
check_circle≤3.5 min results — fastest published LAMP time-to-positive
check_circle10× more sensitive than NEB WarmStart (USDA-funded, J AOAC Int 2022) — PMID 35575315
check_circleOutperforms GspM2.0, GspM, Tin exo in fluorometric LAMP comparison
check_circleEiken Chemical LAMP license — commercial use cleared; open platform compatible with any LAMP primer set
Molecular Testing Anywhere — Genie® III, IP62, Full-Day Battery
The Genie III runs real-time LAMP at constant 65°C from a full-day Lithium-Polymer battery — IP62 weatherproofed for outdoor and field deployment. Dual-color fluorescence. Bluetooth and WiFi data transmission to central reporting. In a published clinical study of 230 human specimens, the Genie III achieved 98.8% sensitivity and 97.7% specificity — comparable to qPCR, without the infrastructure.
check_circleIP62 weatherproofed — outdoor and field deployment
check_circleFull-day Lithium-Polymer battery — no AC power required
check_circleDual-color fluorescence, Bluetooth + WiFi connectivity
check_circle98.8% sensitivity published — independent clinical study (PMID 33809454)
Salmonella LAMP Validated per FDA BAM Methodology — USDA-Commissioned Study
A USDA-commissioned study published in J AOAC Int tested a Salmonella LAMP assay across GspSSD, GspSSD2.0, and NEB WarmStart on the Genie II platform and ABI 7500 Fast in seven animal food matrices. GspSSD2.0 delivered the fastest results (≤3.5 min) and performance consistent with the BAM method.
check_circleSalmonella LAMP validated across 7 animal food matrices
check_circlePerformance “similar to BAM method for detecting fractional positive results”
check_circleDown to single-cell level detection with GspSSD2.0
check_circleTested on Genie II platform (LAMP) and ABI 7500 Fast (qPCR equivalent)
Instrument Selection
Find the perfect Genie platform for your throughput requirements.
Genie II
$22,100.11
Samples16 (2×8-tube strips)
DetectionSingle-channel fluorescence
Power100–240V AC or battery
Result TimeFrom 7 min (DNA)
Best ForMid-volume bench lab
Most Popular
Genie III
$22,100.11
Samples8 (1×8-tube strip)
DetectionDual-color fluorescence
PowerFull-day Li-Po battery
WeatherproofIP62 ✓
Best ForField & outreach sites
Genie HT
$34,999.99
$75,000 new list Refurbished by Pro-Lab Diagnostics
Samples96 (12×8-tube strips, random access)
DetectionDual-channel (4-zone PID)
Power100–240V AC
ConnectivityBT 2.0, WiFi, USB, RJ45
Best ForHigh-throughput clinical lab
ISO-001 GspSSD™ LF
ISO 13485Eiken LicensedCold-Ship Next-Day
$1,003.59 / 400 reactions
$2.51/rxn
GspSSD LF DNA Polymerase LAMP mastermix. Compatible with Genie II and generic qPCR instruments. 400 reactions per kit.
RECOMMENDED
ISO-004 GspSSD2.0™
ISO 13485Eiken LicensedCold-Ship Next-Day
$1,003.59 / 300 reactions
$3.35/rxn
GspSSD2.0 LF — the fastest LAMP enzyme in published head-to-head comparison. ≤3.5 min time-to-positive. Compatible with Genie II, III, and HT. 300 reactions per kit.
10× more sensitive than NEB WarmStart — Domesle et al., J AOAC Int 2022 — PMID 35575315
Optigene Products
ISO-001 GspSSD LF
$1,003.59
400 reactions · $2.51/rxn
ISO-004 GspSSD2.0
$1,003.59
300 reactions · $3.35/rxn
Genie Strips — 500
$830.95
4,000 tests · $0.21/test
Genie Strips — 50
$122.09
400 tests · $0.31/test
Technical Specifications
Feature
Genie II
Genie III
Genie HT
Pro-Lab Direct Price
$22,100.11
$22,100.11
$34,999.99 (Refurbished by Pro-Lab Diagnostics)
List Price
$22,100.11
$22,100.11
$75,000.00 new
Samples/Run
16 (2×8)
8 (1×8)
96 (12×8, random access)
Fluorescence
Single-channel
Dual-color
Dual-channel (470nm + 590nm)
Temperature
Isothermal 65°C
Isothermal 65°C
Ambient–100°C ±0.1°C 4-zone PID
Power
AC or battery
Full-day Li-Po battery
100–240V AC
Weatherproof
—
IP62 ✓
—
Connectivity
Standalone
Bluetooth + WiFi
BT 2.0, WiFi, USB, RJ45
Result Time
From 7 min (DNA), 20 min (RNA)
—
—
ISO 13485
✓ NQA-ANAB
✓ NQA-ANAB
✓ NQA-ANAB
Spec
ISO-001
ISO-004
ISO-001TIN
Price
$1,003.59
$1,003.59
$912.36
Rxns/Kit
400
300
300
$/rxn
$2.51
$3.35
$3.04
Enzyme
GspSSD LF
GspSSD2.0 LF
Tin DNA Polymerase (GspSSD)
Compatible
Genie II, generic qPCR
Genie II, III, HT, generic qPCR
Genie II
LAMP License
Eiken Chemical
Eiken Chemical
Eiken Chemical
Shipping
Cold-ship next-day
Cold-ship next-day
Cold-ship next-day
Frequently Asked Questions
No — LAMP runs at a constant 65°C. No thermal cycling, no ramp programming, no PCR-certified operator or facility space required. DNA amplification begins in as little as 7 minutes on the Genie II and as little as 3.5 minutes using GspSSD2.0 mastermix per independent published data. [Domesle et al., J AOAC Int 2022, PMID 35575315]
In an independent USDA-commissioned study, GspSSD2.0 delivered results in ≤3.5 minutes while NEB WarmStart showed 10-fold lower sensitivity in the same Salmonella LAMP assay across 7 animal food matrices. This is a USDA FSIS peer-reviewed study — not a manufacturer claim. [Domesle et al., J AOAC Int 2022, PMID 35575315]
In a published clinical study of 230 human specimens, the Genie III achieved 98.8% sensitivity and 97.7% specificity for visceral leishmaniasis, and 100% sensitivity and 100% specificity for cutaneous leishmaniasis. The study was independently funded by EU and German government grants. [Ibarra-Meneses et al., Microorganisms 2021, PMID 33809454]
ISO-001 uses GspSSD LF polymerase (400 reactions, $2.51/rxn) for Genie II and generic qPCR. ISO-004 uses GspSSD2.0 LF — the improved second-generation enzyme (300 reactions, $3.35/rxn) — and adds Genie III compatibility. ISO-004 is recommended for fastest results and highest sensitivity.
Yes — all Optigene ISO-001, ISO-004, and ISO-001TIN mastermixes are fully licensed under Eiken Chemical Company’s LAMP patent portfolio. This is stated explicitly on each product listing.
The Genie HT supports 96 samples per run (12 modular 8-tube strip blocks) with full random access and dual-channel fluorescence. New list price is $75,000.00. Pro-Lab Direct offers units refurbished by Pro-Lab Diagnostics at $34,999.99 — 53% below new list.
The Genie platform is not appropriate for: (1) applications requiring multiplex detection of more than two targets simultaneously — qPCR or syndromic panel instruments are better suited; (2) applications requiring quantitative result reporting (Ct value or copy number) — LAMP provides qualitative or time-to-positive results only; (3) FDA-cleared finished diagnostic assays — Optigene sells an open platform, not cleared assays.
Yes — ISO-001, ISO-004, and ISO-001TIN are cold-ship items requiring next-day delivery. This is standard for enzyme-based molecular reagents. The Genie instruments themselves have no cold chain requirement.
Complete Your Genie® LAMP Workflow
Your Genie instrument is only as good as its RNA input. Pro-Mag™ PLM-2000 is the extraction kit validated for LAMP workflows — same ISO 13485 vendor ecosystem, no centrifuge required.
PLM-2000 · 100 Preparations
Pro-Mag™ RNA Extraction Kit
Silica-coated magnetic beads. No spin columns, no centrifuge required. LAMP-validated, RNase-free QC on every buffer lot. ISO 13485 manufactured by Pro-Lab Diagnostics.
Validated for LAMP — confirmed manufacturer claim
No centrifuge — optional magnetic rack accessories (PLM-2001/2002/2003)
RNase-free QC — every buffer lot tested before release
Bst polymerase — the enzyme that powers LAMP — is significantly more sensitive to inhibitors than Taq. Heme, humic acids, and protein carryover that PCR tolerates will block LAMP entirely. Your extraction kit needs to meet a higher purity standard.
verified
Single-vendor validation simplifies your QMS
Both PLM-2000 and Optigene Genie instruments are available through pro-lab-direct.com from the same Pro-Lab Diagnostics ISO 13485 vendor ecosystem — one supplier qualification covers your extraction and detection.
science
No major competitor publishes LAMP validation
As of April 2026, no major RNA extraction kit manufacturer (Qiagen, Thermo, Zymo) explicitly validates their product for LAMP. Pro-Mag™ PLM-2000 closes this pre-analytical gap.
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